diff --git a/meta/recipes-devtools/python/python_2.7.3.bb b/meta/recipes-devtools/python/python_2.7.3.bb
index c181933a64..aace95e729 100644
--- a/meta/recipes-devtools/python/python_2.7.3.bb
+++ b/meta/recipes-devtools/python/python_2.7.3.bb
@@ -122,6 +122,9 @@ PACKAGE_PREPROCESS_FUNCS += "py_package_preprocess"
 py_package_preprocess () {
 	# copy back the old Makefile to fix target package
 	install -m 0644 Makefile.orig ${PKGD}/${libdir}/python${PYTHON_MAJMIN}/config/Makefile
+
+	# Remove references to buildmachine paths in target Makefile
+	sed -i -e 's:--sysroot=${STAGING_DIR_TARGET}::g' -e s:'--with-libtool-sysroot=${STAGING_DIR_TARGET}'::g ${PKGD}/${libdir}/python${PYTHON_MAJMIN}/config/Makefile
 }
 
 require python-${PYTHON_MAJMIN}-manifest.inc