diff --git a/main/iostream.c b/main/iostream.c
index 22cd5985c4..6187bc2fbb 100644
--- a/main/iostream.c
+++ b/main/iostream.c
@@ -465,19 +465,19 @@ int ast_iostream_close(struct ast_iostream *stream)
 					SSL_get_error(stream->ssl, res));
 			}
 
-#if defined(OPENSSL_API_COMPAT) && OPENSSL_API_COMPAT >= 0x10100000L
+#if defined(OPENSSL_VERSION_NUMBER) && OPENSSL_VERSION_NUMBER >= 0x10100000L
 			if (!SSL_is_server(stream->ssl)) {
 #else
 			if (!stream->ssl->server) {
 #endif
 				/* For client threads, ensure that the error stack is cleared */
-#if !defined(OPENSSL_API_COMPAT) || OPENSSL_API_COMPAT < 0x10100000L
+#if !defined(OPENSSL_VERSION_NUMBER) || OPENSSL_VERSION_NUMBER < 0x10100000L
 #if OPENSSL_VERSION_NUMBER >= 0x10000000L
 				ERR_remove_thread_state(NULL);
 #else
 				ERR_remove_state(0);
 #endif	/* OPENSSL_VERSION_NUMBER >= 0x10000000L */
-#endif  /* !defined(OPENSSL_API_COMPAT) || OPENSSL_API_COMPAT < 0x10100000L */
+#endif  /* !defined(OPENSSL_VERSION_NUMBER) || OPENSSL_VERSION_NUMBER < 0x10100000L */
 			}
 
 			SSL_free(stream->ssl);
diff --git a/main/libasteriskssl.c b/main/libasteriskssl.c
index 9905b150c9..36982e2be1 100644
--- a/main/libasteriskssl.c
+++ b/main/libasteriskssl.c
@@ -72,7 +72,7 @@ static void ssl_lock(int mode, int n, const char *file, int line)
 	}
 }
 
-#if !defined(OPENSSL_API_COMPAT) || OPENSSL_API_COMPAT < 0x10100000L
+#if !defined(OPENSSL_VERSION_NUMBER) || OPENSSL_VERSION_NUMBER < 0x10100000L
 int SSL_library_init(void)
 {
 #if defined(AST_DEVMODE)
@@ -114,7 +114,7 @@ void ERR_free_strings(void)
 {
 	/* we can't allow this to be called, ever */
 }
-#endif /* !defined(OPENSSL_API_COMPAT) || OPENSSL_API_COMPAT < 0x10100000L */
+#endif /* !defined(OPENSSL_VERSION_NUMBER) || OPENSSL_VERSION_NUMBER < 0x10100000L */
 
 #endif /* HAVE_OPENSSL */